Trisomy 21, a consequence of advanced maternal age
نویسندگان
چکیده
منابع مشابه
Maternal age and origin of non-disjunction in trisomy 21.
The role of maternal age in chromosomal non-disjunction was investigated by studying 51 families in whom the origin of the meiotic anomaly had been identified. Results of this study were compared with previously published data. This comparison did not show any difference in mean maternal age, nor in distribution of maternal ages when the origin of non-disjunction was maternal, or paternal, or o...
متن کاملMaternal age- and gestation-specific risk for trisomy 21.
OBJECTIVE To provide estimates of maternal age- and gestational age-related risks for trisomy 21. METHODS The prevalence of trisomy 21 was examined in 57,614 women who had fetal karyotyping at 9-16 weeks of gestation for the sole indication of maternal age of 35 years or more. On the basis of the maternal age distribution and the reported maternal age-related risk for trisomy 21 at birth, the...
متن کاملMaternal Germinal Trisomy 21 in Down Syndrome
It has now been over 50 years since it was discovered that Down syndrome is caused by an extra chromosome 21, i.e., trisomy 21. In the interim, it has become clear that in the majority of cases, the extra chromosome is inherited from the mother, and there is, in this respect, a strong maternal age effect. Numerous investigations have been devoted to clarifying the underlying mechanism, most rec...
متن کاملAsymptomatic Celiac Disease in Children with Trisomy 21 at 26 Months of Age or Less
We report three cases of asymptomatic celiac disease identified in children with Down syndrome after being screened at around twenty-four months of age. These cases raise the question as to what age is screening for celiac disease indicated in a child with Down syndrome and no symptoms.
متن کاملMaternal Age-Specific Rates for Trisomy 21 and Common Autosomal Trisomies in Fetuses from a Single Diagnostic Center in Thailand
To provide maternal age-specific rates for trisomy 21 (T21) and common autosomal trisomies (including trisomies 21, 18 and 13) in fetuses. We retrospectively reviewed prenatal cytogenetic results obtained between 1990 and 2009 in Songklanagarind Hospital, a university teaching hospital, in southern Thailand. Maternal age-specific rates of T21 and common autosomal trisomies were established usin...
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ژورنال
عنوان ژورنال: Dar Es Salaam Medical Students' Journal
سال: 1970
ISSN: 0856-7212,0856-7212
DOI: 10.4314/dmsj.v19i1.1